CYP2A6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP2A6.
Immunogen
A synthetic peptide corresponding to CYP2A6.
Host
Rabbit
Theoretical MW (kDa)
56
Reactivity
Human
Specificity
CYP2A6 polyclonal antibody detects endogenous levels of CYP2A6 protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate with CYP2A6 polyclonal antibody (Cat # PAB24904).Immunofluorescence
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Gene Info — CYP2A6
Entrez GeneID
1548Gene Name
CYP2A6
Gene Alias
CPA6, CYP2A, CYP2A3, P450C2A, P450PB
Gene Description
cytochrome P450, family 2, subfamily A, polypeptide 6
Gene Ontology
HyperlinkGene Summary
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq
Other Designations
coumarin 7-hydroxylase|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 3|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
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