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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

Gene Name

LATS1

Gene Alias

WARTS, wts

Gene Description

LATS, large tumor suppressor, homolog 1 (Drosophila)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq

Other Designations

LATS (large tumor suppressor, Drosophila) homolog 1|LATS homolog 1

Entrez GeneID

Gene Name

LATS2

Gene Alias

FLJ13161, KPM

Gene Description

LATS, large tumor suppressor, homolog 2 (Drosophila)

Omim ID

Gene Ontology

Gene Summary

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq

Other Designations

LATS (large tumor suppressor, Drosophila) homolog 2|LATS, large tumor suppressor, homolog 2|OTTHUMP00000018106|kinase phosphorylated during mitosis protein|serine/threonine kinase KPM|warts-like kinase