KAT5 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KAT5.
Immunogen
A synthetic peptide corresponding to human KAT5.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to KAT5.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using KAT5 polyclonal antibody (Cat # PAB18305).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HeLa cells, using KAT5 polyclonal antibody (Cat # PAB18305).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — KAT5
Entrez GeneID
10524Protein Accession#
Q92993Gene Name
KAT5
Gene Alias
ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, cPLA2
Gene Description
K(lysine) acetyltransferase 5
Omim ID
601409Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
Other Designations
HIV-1 Tat interactive protein, 60kDa|K-acetyltransferase 5|Tat interacting protein, 60kDa|cPLA2 interacting protein
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Interactomes
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Publication Reference
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Quantifying Tip60 (Kat5) stratifies breast cancer.
McGuire A, Casey MC, Shalaby A, Kalinina O, Curran C, Webber M, Callagy G, Holian E, Bourke E, Kerin MJ, Brown JAL.
Scientific Reports 2019 Mar; 9(1):3819.
Application:IHC-P, Human, Human breast cancer specimens, BT474, MCF7, MCF10A, MDA-MB-231 cells.
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Identification of a larger form of the histone acetyl transferase Tip60.
Legube G, Trouche D.
Gene 2003 May; 310:161.
Application:WB, Human, HeLa, NIH/3T3, U-2 OS cells.
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PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production.
Sheridan AM, Force T, Yoon HJ, O'Leary E, Choukroun G, Taheri MR, Bonventre JV.
Molecular and Cellular Biology 2001 Jul; 21(14):4470.
Application:IF, WB-Ce, Rat, Mesangial cell.
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Quantifying Tip60 (Kat5) stratifies breast cancer.
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