CEBPA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CEBPA.
Immunogen
A synthetic peptide corresponding to residues surrounding threonine 222 of human CEBPA.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total CEBPA protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from COS-7 cells, treated with EGF (200 ng/ml, 30 mins), using CEBPA polyclonal antibody (Cat # PAB17302).
Peptide "+" means "with peptide blocking". -
Gene Info — CEBPA
Entrez GeneID
1050Protein Accession#
P49715Gene Name
CEBPA
Gene Alias
C/EBP-alpha, CEBP
Gene Description
CCAAT/enhancer binding protein (C/EBP), alpha
Gene Ontology
HyperlinkGene Summary
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq
Other Designations
CCAAT/enhancer binding protein alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.
Choi BH, Park GT, Rho HM.
The Journal of Biological Chemistry 1999 Jan; 274(5):2858.
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Transcription factor C/EBPalpha: novel sites of expression and cloning of the human gene.
Swart GW, van Groningen JJ, van Ruissen F, Bergers M, Schalkwijk J.
Biological Chemistry 1997 May; 378(5):373.
Application:IHC, Human, Skin.
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Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha).
Antonson P, Xanthopoulos KG.
Biochemical and Biophysical Research Communications 1995 Oct; 215(1):106.
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Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.
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