ATM polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ATM.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human ATM.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ATM in Daudi whole cell lysate with ATM polyclonal antibody (Cat # PAB12971) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ATM in human lymph node tissue with ATM polyclonal antibody (Cat # PAB12971) at 2.5 ug/mL . -
Gene Info — ATM
Entrez GeneID
472Protein Accession#
AAB65827Gene Name
ATM
Gene Alias
AT1, ATA, ATC, ATD, ATDC, ATE, DKFZp781A0353, MGC74674, TEL1, TELO1
Gene Description
ataxia telangiectasia mutated
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein|human phosphatidylinositol 3-kinase homolog|serine-protein kinase ATM
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Interactome
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Pathway
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Disease
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Publication Reference
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Mechanisms of eukaryotic DNA double strand break repair.
Cahill D, Connor B, Carney JP.
Frontiers in Bioscience 2006 May; 11:1958.
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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.
Dasika GK, Lin SC, Zhao S, Sung P, Tomkinson A, Lee EY.
Oncogene 1999 Dec; 18(55):7883.
Application:WB-Ce, WB-Tr, Human, Mouse, Mammalian cells, MEFs.
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Mechanisms of eukaryotic DNA double strand break repair.
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