TFPI polyclonal antibody
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Specification
Product Description
Sheep polyclonal antibody raised against a C-terminal truncated recombinant TFPI molecule comprised of domains 1 and 2.
Immunogen
Recombinant protein corresponding to C-terminus truncated TFPI molecule comprised of regions 1 and 2.
Host
Sheep
Reactivity
Human
Specificity
This antibody recognizes human tissue factor pathway inhibitor.
Form
Liquid
Recommend Usage
Western Blot (25 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TFPI
Entrez GeneID
7035Gene Name
TFPI
Gene Alias
EPI, LACI, TFI, TFPI1
Gene Description
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Omim ID
152310Gene Ontology
HyperlinkGene Summary
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq
Other Designations
OTTHUMP00000163472|anti-convertin|extrinsic pathway inhibitor|lipoprotein-associated coagulation inhibitor|tissue factor pathway inhibitor
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Interactome
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Pathway
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Disease
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Publication Reference
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Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz–type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor.
Hansen L, Petersen LC, Lauritzen B, Clausen JT, Grell SN, Agerso H, Sorensen BB, Hilden I, Almholt K.
Thrombosis Research 2014 Mar; 133(3):464.
Application:IF, Rabbit, Skin, Liver, Aorta, Spleen, Striated skeletal muscle.
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Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz–type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor.
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