GFRA3 (Human) Recombinant Protein
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Specification
Product Description
Human GFRA3 partial recombinant protein with His tag in N-terminus expressed in Escherichia coli.
Sequence
MGSSHHHHHHSSGLVPRGSHMGSDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLAHQNENPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMRKAYGEACSG
Host
Escherichia coli
Theoretical MW (kDa)
40.7
Form
Liquid
Preparation Method
Escherichia coli expression system
Purification
chromatographic
Purity
> 85% as determined by SDS-PAGE.
Activity
ED50 < 1.0 ng/mL, measured by the dose-dependant stimulation of the proliferation of human AML5 cells, corresponding to a specific activity of > 1.0 x 106 IU/mg.
Storage Buffer
Solution (1 mg/mL) containing 20 mM Tris-HCl, pH 8.0, 10% glycerol, 0.4 M urea.
Storage Instruction
Store at 4°C for 2-4 weeks and should be stored at -20°C to -80°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — GFRA3
Entrez GeneID
2676Protein Accession#
O60609Gene Name
GFRA3
Gene Alias
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Gene Description
GDNF family receptor alpha 3
Omim ID
605710Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq
Other Designations
GPI-linked receptor|glial cell line-derived neurotrophic factor receptor alpha-3
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Interactome
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Disease
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