TNFRSF10A (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF10A (O00220) recombinant protein expressed in E. Coli.
Sequence
SGTGAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSERPGACNRCTEGVGYTNASQQLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSTGCPRGMVKVKDCTPWSDIECVHKESGNGHN
Host
Escherichia coli
Theoretical MW (kDa)
24
Form
Lyophilized
Purity
> 95%
Endotoxin Level
<= 1 EUs/ug (LAL gel clot method)
Activity
Measured by the ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4 -0.5 ug/mL.
Storage Buffer
Lyophilized from PBS, pH 7.2.
Storage Instruction
Stored at -20°C to-80°C.
After reconstitution with sterile water not less than 0.1 mg/mL, store at -20°C to -80°C for 6 months, store at 4°C for 1 month.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Functional Study
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Gene Info — TNFRSF10A
Entrez GeneID
8797Protein Accession#
O00220Gene Name
TNFRSF10A
Gene Alias
APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1
Gene Description
tumor necrosis factor receptor superfamily, member 10a
Omim ID
603611Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq
Other Designations
TNF-related apoptosis inducing ligand receptor 1|cytotoxic TRAIL receptor|death receptor 4
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