XPA monoclonal antibody, clone 5F12
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More Files
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Western Blot (Cell lysate)
Detection of XPA protein in crude extract of HeLa cell by western blotting, using XPA monoclonal antibody, clone 5F12 (Cat # MAB6747).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant XPA.
Immunogen
Recombinant protein corresponding to full length human XPA.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
Western Blot (0.1-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol)
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Detection of XPA protein in crude extract of HeLa cell by western blotting, using XPA monoclonal antibody, clone 5F12 (Cat # MAB6747).Enzyme-linked Immunoabsorbent Assay
Inhibition Assay
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Gene Info — XPA
Entrez GeneID
7507Gene Name
XPA
Gene Alias
XP1, XPAC
Gene Description
xeroderma pigmentosum, complementation group A
Gene Ontology
HyperlinkGene Summary
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000021751|excision repair-controlling
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.
Saijo M, Matsuda T, Kuraoka I, Tanaka K.
Biochemical and Biophysical Research Communications 2004 Sep; 321(4):815.
Application：ELISA, WB, Human, HeLa cells.
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Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain.
Tanaka K, Miura N, Satokata I, Miyamoto I, Yoshida MC, Satoh Y, Kondo S, Yasui A, Okayama H, Okada Y.
Nature 1990 Nov; 348(6296):73.
Application：IP, Human, Mammalian cells.
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Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.
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