PLAT monoclonal antibody, clone 629-2A153
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant PLAT.
Immunogen
Recombinant protein corresponding to human PLAT.
Host
Mouse
Reactivity
Human
Specificity
This epitope is localized to the heavy chain of human tPA and binds well to both the free and complexed form.
Form
Liquid
Isotype
IgG
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 1 mM NaCl, pH 6.6
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Lane 1. Human PLAT.
Lane 2. PLAT in complex with Serpine1.
Lane 3. Retavase Boehringer/Mannheim (PLAT fragment).
Lane 4. Retavase in complex with Serpine1.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PLAT
Entrez GeneID
5327Gene Name
PLAT
Gene Alias
DKFZp686I03148, T-PA, TPA
Gene Description
plasminogen activator, tissue
Omim ID
173370Gene Ontology
HyperlinkGene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)
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Interactome
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Pathway
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Disease
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