CASP5 monoclonal antibody, clone GOI-3
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More Files
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Western Blot (Cell lysate)
Western Blot analysis of HeLa cell lysate with CASP5 monoclonal antibody, clone GOI-3 (Cat # MAB19694).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human CASP5.
Immunogen
A synthetic peptide corresponding to human CASP5.
Host
Rabbit
Theoretical MW (kDa)
49.736
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:200)
Immunoprecipitation (1:50)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of HeLa cell lysate with CASP5 monoclonal antibody, clone GOI-3 (Cat # MAB19694).Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
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Gene Info — CASP5
Entrez GeneID
838Protein Accession#
P51878Gene Name
CASP5
Gene Alias
ICE(rel)III, ICEREL-III, ICH-3, MGC141966
Gene Description
caspase 5, apoptosis-related cysteine peptidase
Omim ID
602665Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000045729|TY protease|caspase 5|caspase 5, apoptosis-related cysteine protease
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Interactome
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Disease
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