PTPRC monoclonal antibody, clone MEM-28
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More Files
- More Functions
Flow Cytometry
Surface staining of human peripheral blood cells with PTPRC monoclonal antibody, clone MEM - 28 (Cat # MAB0886) APC.
Immunofluorescence (Circulating Tumor Cell)
PBMCs were stained with CD45-R-PE labeled monoclonal antibody (Red). The cell nucleus were counterstained with DAPI (Blue).
Immunofluorescence
Immunofluorescence of monoclonal antibody to CD45 on PBMCs cell . [antibody concentration 10 ug/ml]
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Specifications
Product Description
Mouse monoclonal antibody raised against native PTPRC.
Immunogen
Native purified PTPRC from human thymocytes and T lymphocytes.
Host
Mouse
Theoretical MW (kDa)
180-220
Reactivity
Human
Specificity
This antibody reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 KDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.
Form
Liquid
Concentration
1 mg/mL
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoprecipitation
Flow Cytometry
Surface staining of human peripheral blood cells with PTPRC monoclonal antibody, clone MEM - 28 (Cat # MAB0886) APC.Immunofluorescence (Circulating Tumor Cell)
PBMCs were stained with CD45-R-PE labeled monoclonal antibody (Red). The cell nucleus were counterstained with DAPI (Blue).Immunofluorescence
Immunofluorescence of monoclonal antibody to CD45 on PBMCs cell . [antibody concentration 10 ug/ml] -
Gene Info — PTPRC
Entrez GeneID
5788Gene Name
PTPRC
Gene Alias
B220, CD45, CD45R, GP180, LCA, LY5, T200
Gene Description
protein tyrosine phosphatase, receptor type, C
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations
CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|glycoprotein|leukocyte-common antigen|protein tyrosine phosphatase, receptor type, c polypeptide
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Interactomes
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Pathways
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Diseases
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