Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

SNW1

Gene Alias

Bx42, MGC119379, NCOA-62, PRPF45, Prp45, SKIIP, SKIP

Gene Description

SNW domain containing 1

Omim ID

Gene Ontology

Gene Summary

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq

Other Designations

SKI interacting protein|SKI-interacting protein|homolog of Drosophila BX42|nuclear protein SkiP|nuclear receptor coactivator, 62-kD