AML1/ETO DY Translocation FISH Probe

Catalog # FT0003

Size

Price

Stock

Quantity

Size:100 uL
Price: USD $ 1,288.00
Stock:
order now, ship in 5 days
abnova-minus
abnova-plus
Size:200 uL
Price: USD $ 2,122.00
Stock:
order now, ship in 5 days
abnova-minus
abnova-plus

* The price is valid only in USA. Please select country.

Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Fluorescent <i>In Situ</i> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Application

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human lymph node (FFPE) stained with AML1/ETO DY Translocation FISH Probe. Human lymph node cancer showed no AML1/ETO DY Translocation.

QC Test

<br>Hybridization position of the probes on the chromosome.
Note


Hybridization position of the probes on the chromosome.


Hybridization position of the probes on the chromosome.

  • Specification

    Product Description

    Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology)

    Probe 1

    Name: AML1
    Size: Approximately 1340kb
    Fluorophore: FITC
    Location: 21q22.12

    Probe 2

    Name: ETO
    Size: Approximately 1110kb
    Fluorophore: Texas Red
    Location: 8q21.3

    Reactivity

    Human

    Form

    Liquid

    Notice

    We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.

    Regulation Status

    For research use only (RUO)

    Quality Control Testing

    Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    Supplied Product

    DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe

    Storage Instruction

    Store at 4°C in the dark.

    Note


    Hybridization position of the probes on the chromosome.

  • Applications

    Fluorescent In Situ Hybridization (Cell)

    Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

    Human lymph node (FFPE) stained with AML1/ETO DY Translocation FISH Probe. Human lymph node cancer showed no AML1/ETO DY Translocation.
  • Gene Info — RUNX1

    Entrez GeneID

    861

    Gene Name

    RUNX1

    Gene Alias

    AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2aB

    Gene Description

    runt-related transcription factor 1

    Omim ID

    151385 180300 601399 601626

    Gene Ontology

    Hyperlink

    Gene Summary

    Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    AML1-EVI-1 fusion protein|acute myeloid leukemia 1|aml1 oncogene|core-binding factor, runt domain, alpha subunit 2

  • Gene Info — RUNX1T1

    Entrez GeneID

    862

    Gene Name

    RUNX1T1

    Gene Alias

    AML1T1, CBFA2T1, CDR, ETO, MGC2796, MTG8, MTG8b, ZMYND2

    Gene Description

    runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

    Omim ID

    133435

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    acute myelogenous leukemia 1 translocation 1 protein|acute myelogenous leukemia 1 translocation 1, cyclin-D related|core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related|eight twenty one protein|myeloid translocation gene

  • Interactome
  • Pathway
  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
4 Products to Compare
Remove All