mutaFISH™ TERTwt RNA Probes
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Specification
Product Description
mutaFISH™ TERTwt RNA Probes is designed to detect human TERT gene on single strand RNA in cells using padlock probe and in situ rolling-circle amplification technology.
Reactivity
Human
Supplied Product
Content:
1. RT TERT Primer
2. mutaFISH™ TERTwt RNA Probe
3. Detection Probe-6-HEXComparison
Fluorophore
6-HEX (Excitation Peak (nm): 533; Emission Peak (nm): 559)
Probe Position
Regulatory Status
For research use only (RUO)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
We recommend mutaFISH™ RNA Accessory Kit (Catalog #: KA4915) which provides necessary reagents and enzymes for in situ reverse transcription, RNA digestion, mutaFISH™ hybridization, ligation and amplication prior to mutaFISH™.
Video
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Applications
mutation specific, Fluorescence In Situ Hybridization (Cells)
mutaFISH™ staining was performed in situ in human SK-N-BE2 cells. TERT was detected via purple signal (Texas Red). -
Gene Info — TERT
Entrez GeneID
7015Gene Name
TERT
Gene Alias
EST2, TCS1, TP2, TRT, hEST2
Gene Description
telomerase reverse transcriptase
Gene Ontology
HyperlinkGene Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq
Other Designations
telomerase catalytic subunit
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Interactome
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Disease
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