PKN1 recombinant monoclonal antibody, clone R09-2I4
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PKN1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human PKN1.
Theoretical MW (kDa)
Calculated MW: 104 k
Reactivity
Rat
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
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Gene Info — PKN1
Entrez GeneID
5585Protein Accession#
Q16512Gene Name
PKN1
Gene Alias
DBK, MGC46204, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
Gene Description
protein kinase N1
Omim ID
601032Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
protein kinase C-like 1|protein kinase C-like PKN|protein kinase C-related kinase 1|serine-threonine kinase N|serine/threonine protein kinase N
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Interactome
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Disease
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