SDHB recombinant monoclonal antibody, clone 7D12
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: 293 whole cell lysate; Lane 2: K562 whole cell lysate; Lane 3: NIH/3T3 whole cell lysate; Lane 4: PC-3 whole cell lysate; Lane 5: Rat heart tissue; Lane 6: Mouse heart tissue; Lane 7: Mouse liver tissue.
Immunohistochemistry
Immunohistochemistry image of SDHB recombinant monoclonal antibody, clone 7D12 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system.
Flow Cytometry
Overlay histogram showing 293 cells stained with SDHB recombinant monoclonal antibody, clone 7D12 (red line) at 1:50.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human, mouse and rat SDHB.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human SDHB.
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry (1:20-1:200)
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: 293 whole cell lysate; Lane 2: K562 whole cell lysate; Lane 3: NIH/3T3 whole cell lysate; Lane 4: PC-3 whole cell lysate; Lane 5: Rat heart tissue; Lane 6: Mouse heart tissue; Lane 7: Mouse liver tissue.Immunohistochemistry
Immunohistochemistry image of SDHB recombinant monoclonal antibody, clone 7D12 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Overlay histogram showing 293 cells stained with SDHB recombinant monoclonal antibody, clone 7D12 (red line) at 1:50. -
Gene Info — SDHB
Entrez GeneID
6390Protein Accession#
P21912Gene Name
SDHB
Gene Alias
FLJ92337, IP, PGL4, SDH, SDH1, SDHIP
Gene Description
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Ontology
HyperlinkGene Summary
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq
Other Designations
OTTHUMP00000002396|OTTHUMP00000044624|iron-sulfur subunit
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Interactome
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Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Metabolic pathways
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