RPE65 recombinant monoclonal antibody, clone 7B10
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More Files
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Immunohistochemistry
Immunohistochemistry image of RPE65 recombinant monoclonal antibody, clone 7B10 diluted at 1:100 and staining in paraffin-embedded human eye tissue performed on a Leica BondTM system.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human RPE65.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human RPE65.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of RPE65 recombinant monoclonal antibody, clone 7B10 diluted at 1:100 and staining in paraffin-embedded human eye tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RPE65
Entrez GeneID
6121Protein Accession#
Q16518Gene Name
RPE65
Gene Alias
LCA2, RP20, mRPE65, rd12, sRPE65
Gene Description
retinal pigment epithelium-specific protein 65kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq
Other Designations
OTTHUMP00000010788|RBP-binding membrane protein|p63|retinal pigment epithelium-specific 61 kDa protein|retinal pigment epithelium-specific protein (65kD)|retinitis pigmentosa 20 (autosomal recessive)
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Interactome
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Pathway
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Disease
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