COL17A1 recombinant monoclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded mouse skin tissue using COL17A1 recombinant monoclonal antibody (Cat # RAB02683). Counter stained with hematoxylin.
Immunocytochemistry
Immunocytochemical staining of HUVEC cells using COL17A1 recombinant monoclonal antibody (Cat # RAB02683)(green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100/PBS.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against COL17A1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant COL17A1.
Theoretical MW (kDa)
130, 180
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of COL17A1 and does not cross-react with related proteins.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:200)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.2 (50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded mouse skin tissue using COL17A1 recombinant monoclonal antibody (Cat # RAB02683). Counter stained with hematoxylin.Immunocytochemistry
Immunocytochemical staining of HUVEC cells using COL17A1 recombinant monoclonal antibody (Cat # RAB02683)(green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100/PBS.Immunofluorescence
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Gene Info — COL17A1
Entrez GeneID
1308Protein Accession#
Q9UMD9Gene Name
COL17A1
Gene Alias
BA16H23.2, BP180, BPAG2, FLJ60881, KIAA0204, LAD-1
Gene Description
collagen, type XVII, alpha 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq
Other Designations
OTTHUMP00000020422|alpha 1 type XVII collagen|bA16H23.2 (collagen, type XVII, alpha 1 (BP180))|bullous pemphigoid antigen 2 (180kD)|collagen XVII, alpha-1 polypeptide
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Interactome
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Disease
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