ANK1 polyclonal antibody (Biotin)
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Specification
Product Description
Chicken polyclonal antibody against synthetic peptide of ANK1.
Immunogen
A Synthetic peptide corresponding to amino acids of ANK1
Sequence
LALQAQPVPDELVTK
Host
Chicken
Reactivity
Human
Form
Liquid
Conjugation
Biotin
Purification
Antigen affinity purification
Concentration
1 mg/mL
Isotype
IgY
Storage Buffer
In Phosphate-Buffered Saline with 0.02% Sodium Azide.
Storage Instruction
Store at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immuno-MRM (multiple reaction monitoring)
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Gene Info — ANK1
Entrez GeneID
286Gene Name
ANK1
Gene Alias
ANK, SPH1, SPH2
Gene Description
ankyrin 1, erythrocytic
Omim ID
182900Gene Ontology
HyperlinkGene Summary
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq
Other Designations
ankyrin 1|ankyrin-1, erythrocytic|ankyrin-R
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