CHUK polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CHUK in HeLa whole cell lysate with CHUK polyclonal antibody (Cat # PAB13399) at 1 : 1000 dilution.
Immunocytochemistry
Immunocytochemistry of CHUK in Jurkat cells with CHUK polyclonal antibody (Cat # PAB13399) at 1 ug/mL .
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CHUK.
Immunogen
A synthetic peptide corresponding to amino acids 716-734 of human CHUK.
Host
Rabbit
Reactivity
Human
Specificity
human IKK alpha differs from corresponding murine sequence by one amino acid. An 85 KDa band should be detected. This antibody has no cross response to IKKb or IKKg.
Form
Liquid
Recommend Usage
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CHUK in HeLa whole cell lysate with CHUK polyclonal antibody (Cat # PAB13399) at 1 : 1000 dilution.Immunocytochemistry
Immunocytochemistry of CHUK in Jurkat cells with CHUK polyclonal antibody (Cat # PAB13399) at 1 ug/mL . -
Gene Info — CHUK
Entrez GeneID
1147Protein Accession#
AF009225Gene Name
CHUK
Gene Alias
IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Gene Description
conserved helix-loop-helix ubiquitous kinase
Omim ID
600664Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq
Other Designations
I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|OTTHUMP00000020273|conserved helix-loop ubiquitous kinase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV.
Science 1997 Oct; 278(5339):866.
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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M.
Nature 1997 Aug; 388(6642):548.
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Identification and characterization of an IkappaB kinase.
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M.
Cell 1997 Jul; 90(2):373.
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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
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