MYC polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of MYC.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MYC.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot of analysis in MYC recombinant protein 5 uL (A) and 2 uL (B) loaded in each lane. -
Gene Info — MYC
Entrez GeneID
4609Gene Name
MYC
Gene Alias
bHLHe39, c-Myc
Gene Description
v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
Other Designations
avian myelocytomatosis viral oncogene homolog|myc proto-oncogene protein|v-myc avian myelocytomatosis viral oncogene homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Competition between targeting signals in hybrid proteins provides information on their relative in vivo affinities for subcellular compartments.
Schmauch C, Maniak M.
European Journal of Cell Biology 2007 Dec; 87(2):57.
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TIF1 activates the intra-S-phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena.
Yakisich JS, Sandoval PY, Morrison TL, Kapler GM.
Molecular Biology of the Cell 2006 Sep; 17(12):5185.
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Competition between targeting signals in hybrid proteins provides information on their relative in vivo affinities for subcellular compartments.
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