RIPK3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of RIP3 in the 1) absence and 2) presence of immunizing peptide in NIH/3T3 cell lysate. Using RIPK3 polyclonal antibody (Cat # PAB0287) at 1 ug/mL .
Immunohistochemistry
IHC analysis of human pancreas. Using RIPK3 polyclonal antibody (Cat # PAB0287) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant RIPK3.
Immunogen
Recombinant protein corresponding to amino acids 480-530 of human RIPK3.
Host
Rabbit
Reactivity
Chimpanzee, Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% gelatin, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of RIP3 in the 1) absence and 2) presence of immunizing peptide in NIH/3T3 cell lysate. Using RIPK3 polyclonal antibody (Cat # PAB0287) at 1 ug/mL .Immunohistochemistry
IHC analysis of human pancreas. Using RIPK3 polyclonal antibody (Cat # PAB0287) at 10 ug/mL . -
Gene Info — RIPK3
Entrez GeneID
11035Gene Name
RIPK3
Gene Alias
RIP3
Gene Description
receptor-interacting serine-threonine kinase 3
Omim ID
605817Gene Ontology
HyperlinkGene Summary
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq
Other Designations
RIP-like protein kinase 3|receptor interacting protein 3
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Interactome
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Disease
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Publication Reference
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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9.
Lena Behrmann, Scott McComb, Júlia Aguadé-Gorgorió, Yun Huang, Mario Hermann, Pawel Pelczar, Adriano Aguzzi, Jean-Pierre Bourquin, Beat C Bornhauser.
Bio-Protocol 2017 Apr; 7(7):e2222.
Application：WB-Ti, WB-Tr, Human, Patient-derived acute lymphoblastic leukemia cells.
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Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion.
Zhao W, Feng H, Sun W, Liu K, Lu JJ, Chen X.
Redox Biology 2017 Jan; 11:524.
Application：WB, Human, HUVEC.
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Differences and similarities in TRAIL-and TNF-mediated necroptotic signaling in cancer cells.
Sosna J, Philipp S, Fuchslocher Chico J, Saggau C, Fritsch J, Foll A, Plenge J, Arenz C, Pinkert T, Kalthoff H, Trauzold A, Schmitz I, Schutze S, Adam D.
Molecular and Cellular Biology 2016 Sep; 36(20):2626.
Application：WB-Ce, Mouse, MEFs.
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TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.
Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, Herdegen T, Linkermann A, Rittger A, Chan FK, Kabelitz D, Schutze S, Adam D.
Cellular and Molecular Life Sciences 2014 Jan; 71(2):331.
Application：WB-Ce, WB-Tr, Mouse, NIH/3T3 cells, MEFs, Lung fibroblasts.
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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9.
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