Products

Enzyme-linked Immunoabsorbent Assay

Functional Study

SDS-PAGE

Entrez GeneID

Protein Accession#

Gene Name

B2M

Gene Alias

-

Gene Description

beta-2-microglobulin

Omim ID

Gene Ontology

Gene Summary

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia

Other Designations

beta chain of MHC class I molecules|beta-2-microglobin

Entrez GeneID

Protein Accession#

Gene Name

HLA-A

Gene Alias

HLAA

Gene Description

major histocompatibility complex, class I, A

Omim ID

Gene Ontology

Gene Summary

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq

Other Designations

HLA class I histocompatibility antigen, A-23 alpha chain|MHC class I antigen HLA-A heavy chain|MHC leukocyte antigen|OTTHUMP00000161059|antigen presenting molecule|leucocyte antigen class I|leukocyte antigen class I-A

Entrez GeneID

Protein Accession#

Gene Name

LAMP2

Gene Alias

CD107b, LAMPB, LGP110

Gene Description

lysosomal-associated membrane protein 2

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq

Other Designations

OTTHUMP00000023943|OTTHUMP00000023944|lysosome-associated membrane protein 2