DES monoclonal antibody, clone 10H7D2
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis using DES monoclonal antibody, clone 10H7D2 (Cat # MAB8300) against truncated DES recombinant protein.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
immunohistochemical analysis of paraffin-embedded human smooth muscle sarcoma, showing cytoplasmic localization, using DES monoclonal antibody, clone 10H7D2 (Cat # MAB8300) with DAB staining.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant DES.
Immunogen
Recombinant protein corresponding to truncated human DES.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:1000-1:2000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2000)
Immunohistochemistry (Frozen sections) (1:1000-1:2000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using DES monoclonal antibody, clone 10H7D2 (Cat # MAB8300) against truncated DES recombinant protein.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
immunohistochemical analysis of paraffin-embedded human smooth muscle sarcoma, showing cytoplasmic localization, using DES monoclonal antibody, clone 10H7D2 (Cat # MAB8300) with DAB staining.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — DES
Entrez GeneID
1674Gene Name
DES
Gene Alias
CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793
Gene Description
desmin
Gene Ontology
HyperlinkGene Summary
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq
Other Designations
OTTHUMP00000064865|intermediate filament protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Desmin modulates lung elastic recoil and airway responsiveness.
Shardonofsky FR, Capetanaki Y, Boriek AM.
American Journal of Physiology. Lung Cellular and Molecular Physiology 2006 May; 290(5):L890.
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Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart.
Huang X, Li J, Foster D, Lemanski SL, Dube DK, Zhang C, Lemanski LF.
Experimental Biology and Medicine (Maywood, N.J.) 2002 Dec; 227(11):1039.
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Desmin modulates lung elastic recoil and airway responsiveness.
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