HLA-DR1 monoclonal antibody, clone MEM-267 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against HLA-DR1.
Immunogen
Purified, insoluble DR1 beta chain (DRB1*0101) expressed in Escherichia coli inclusion bodies.
Host
Mouse
Reactivity
Human
Specificity
This antibody specifically binds to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).
Form
Liquid
Conjugation
PE
Concentration
0.1 mg/mL
Isotype
IgG2b
Recommend Usage
Flow Cytometry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Publication Reference
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Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.
Potolicchio I, Chitta S, Xu X, Fonseca D, Crisi G, Horejsi V, Strominger JL, Stern LJ, Raposo G, Santambrogio L.
Journal of Immunology 2005 Oct; 175(8):4935.
Application:IEM, WB, Human, Monocytes.
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Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding.
Carven GJ, Chitta S, Hilgert I, Rushe MM, Baggio RF, Palmer M, Arenas JE, Strominger JL, Horejsi V, Santambrogio L, Stern LJ.
The Journal of Biological Chemistry 2004 Apr; 279(16):16561.
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Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.
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