PLCG2 (phospho Y753) monoclonal antibody, clone 3A8B6
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis using PLCG2 monoclonal antibody against A431 cell lysate.
Immunocytochemistry
Immunocytochemical staining of Hela cells with PLCG2 monoclonal antibody (green). DRAQ5 fluorescent DNA dye (blue). Actin filaments labeled with Alexa Fluor-555 phalloidin (red).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of PLCG2 monoclonal antibody, clone 3A8B6.
Flow Cytometry
Flow cytometric analysis of Hela cells with PLCG2 monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of human PLCG2.
Immunogen
A synthetic peptide corresponding to amino acid surrounding Y753 of human PLCG2.
Host
Mouse
Theoretical MW (kDa)
148
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunocytochemistry (1:200-1:1000)
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using PLCG2 monoclonal antibody against A431 cell lysate.Immunocytochemistry
Immunocytochemical staining of Hela cells with PLCG2 monoclonal antibody (green). DRAQ5 fluorescent DNA dye (blue). Actin filaments labeled with Alexa Fluor-555 phalloidin (red).Enzyme-linked Immunoabsorbent Assay
ELISA analysis of PLCG2 monoclonal antibody, clone 3A8B6.Flow Cytometry
Flow cytometric analysis of Hela cells with PLCG2 monoclonal antibody (green) and negative control (red). -
Gene Info — PLCG2
Entrez GeneID
5336Gene Name
PLCG2
Gene Alias
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Gene Description
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Omim ID
600220Gene Ontology
HyperlinkGene Summary
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM
Other Designations
phospholipase C gamma 2|phospholipase C, gamma 2|phospholipase C, gamma 2 (phosphatidylyinositol-specific)
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Interactome
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Pathway
- B cell receptor signaling pathway
- Calcium signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glioma
- Inositol phosphate metabolism
- Leukocyte transendothelial migration
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Disease
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