PRNP monoclonal antibody, clone T16-R
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: mouse brain tissue lysate, HEK293 cells transfected with Lane 2: PRNP recombinant protein and Lane 3: empty vector with PRNP monoclonal antibody, clone T16-R (Cat # MAB15907).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human PRNP.
Immunogen
A synthetic peptide corresponding to amino acids 33-46 at N-terminus of human PRNP, just before the first octapeptide repeat.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
EVAC purification
Isotype
IgG
Recommend Usage
ELISA (1:10000-1:20000)
Immunoprecipitation
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl buffer, pH 8.0 (10 mg/mL BSA, 0.05% Sodium Azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: mouse brain tissue lysate, HEK293 cells transfected with Lane 2: PRNP recombinant protein and Lane 3: empty vector with PRNP monoclonal antibody, clone T16-R (Cat # MAB15907).Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRNP
Entrez GeneID
5621Protein Accession#
P04156Gene Name
PRNP
Gene Alias
ASCR, CD230, CJD, GSS, MGC26679, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, prion
Gene Description
prion protein
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
CD230 antigen|OTTHUMP00000030162|OTTHUMP00000030163|major prion protein|p27-30|prion protein PrP|prion-related protein
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Interactome
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Pathway
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Disease
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