HLA-E monoclonal antibody, clone MEM-E/02
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant HLA-E.
Immunogen
Recombinant protein corresponding to heavy chain region (denaturated) of human HLA-E.
Host
Mouse
Reactivity
Human, Primates
Specificity
This antibody specifically reacts with denaturated heavy chain of human HLA-E.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — HLA-E
Entrez GeneID
3133Gene Name
HLA-E
Gene Alias
DKFZp686P19218, EA1.2, EA2.1, HLA-6.2, MHC, QA1
Gene Description
major histocompatibility complex, class I, E
Omim ID
143010Gene Ontology
HyperlinkGene Summary
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq
Other Designations
HLA class I histocompatibility antigen, E alpha chain|MHC HLA-E alpha-1|MHC HLA-E alpha-2.1|MHC class I antigen|OTTHUMP00000029214|lymphocyte antigen
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Interactome
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Pathway
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Disease
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Publication Reference
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Predictive value of HLA-G and HLA-E in the prognosis of colorectal cancer patients.
Guo ZY, Lv YG, Wang L, Shi SJ, Yang F, Zheng GX, Wen WH, Yang AG.
Cellular Immunology 2015 Jan; 293(1):10.
Application:IHC, Human, Colorectal cancer tissues.
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Predictive value of HLA-G and HLA-E in the prognosis of colorectal cancer patients.
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