Products

Western Blot

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunocytochemistry

Immunoprecipitation

Entrez GeneID

Gene Name

KRT5

Gene Alias

CK5, DDD, EBS2, K5, KRT5A

Gene Description

keratin 5

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq

Other Designations

58 kda cytokeratin|epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types|keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)|keratin, type II cytoskeletal 5

Entrez GeneID

Gene Name

KRT8

Gene Alias

CARD2, CK8, CYK8, K2C8, K8, KO

Gene Description

keratin 8

Omim ID

Gene Ontology

Gene Summary

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq

Other Designations

cytokeratin 8|keratin, type II cytoskeletal 8