Cytokeratin recombinant monoclonal antibody, clone KRT/1877R

Catalog # RAB00692

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Size:100 ug
Price: USD $ 479.00
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  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Application

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human skin.

Immunofluorescence
Application

Immunofluorescence

Immunofluorescence staining of MeOH-fixed Human MCF-7 cells labeling CK. This antibody followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).

  • Specifications

    Product Description

    Rabbit recombinant monoclonal antibody raised against human Cytokeratin.Recombinant Antibody,Recombinant Antibodies,Recombinant Monoclonal Antibody,RecomAb,Recombinant Ab,Recombinant Monoclonal Antibodies,Recombinant Abs

    Antibody Species

    Rabbit

    Immunogen

    Keratin-enriched preparation from cultured human epithelial cells.

    Reactivity

    Bovine, Frog, Goat, Guinea pig, Human, Monkey, Mouse, Pig, Rat

    Form

    Liquid

    Purification

    Protein A/G purification

    Isotype

    IgG

    Recommend Usage

    Flow Cytometry (1-2 ug/million cells)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
    Immunofluorescence (1-2 ug/mL)
    Western Blot (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In 1 mg/mL PBS

    Storage Instruction

    Store at -20 to -80°C.
    Aliquot to avoid repeated freezing and thawing.

  • Applications

    Western Blot

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemical staining of human skin.

    Immunofluorescence

    Immunofluorescence staining of MeOH-fixed Human MCF-7 cells labeling CK. This antibody followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).

    Flow Cytometry

  • Gene Info — KRT4

    Entrez GeneID

    3851

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT4

    Gene Alias

    CK4, CYK4, FLJ31692, K4

    Gene Description

    keratin 4

    Omim ID

    123940 193900

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq

    Other Designations

    cytokeratin 4|keratin, type II cytoskeletal 4

  • Gene Info — KRT5

    Entrez GeneID

    3852

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT5

    Gene Alias

    CK5, DDD, EBS2, K5, KRT5A

    Gene Description

    keratin 5

    Omim ID

    131800 131960 148040 179850

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq

    Other Designations

    58 kda cytokeratin|epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types|keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)|keratin, type II cytoskeletal 5

  • Gene Info — KRT6A

    Entrez GeneID

    3853

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT6A

    Gene Alias

    CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D

    Gene Description

    keratin 6A

    Omim ID

    148041 167200

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq

    Other Designations

    56 cytoskeletal type II keratin|K6D keratin|cytokeratin 6A|cytokeratin 6C|cytokeratin 6D|keratin 6C|keratin, epidermal type II, K6A|keratin, epidermal type II, K6C|keratin, type II cytoskeletal 6D|type II keratin isoform K6c

  • Gene Info — KRT6B

    Entrez GeneID

    3854

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT6B

    Gene Alias

    CK6B, K6B, KRTL1, PC2

    Gene Description

    keratin 6B

    Omim ID

    148042 167210

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq

    Other Designations

    cytokeratin 6B|keratin, epidermal, type II, K6B|keratin, type II cytoskeletal 6B|keratin-like 1 (a type II keratin sequence)

  • Gene Info — KRT8

    Entrez GeneID

    3856

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT8

    Gene Alias

    CARD2, CK8, CYK8, K2C8, K8, KO

    Gene Description

    keratin 8

    Omim ID

    148060 215600

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq

    Other Designations

    cytokeratin 8|keratin, type II cytoskeletal 8

  • Gene Info — KRT10

    Entrez GeneID

    3858

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT10

    Gene Alias

    CK10, K10, KPP

    Gene Description

    keratin 10

    Omim ID

    113800 148080 600648 607602

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq

    Other Designations

    cytokeratin 10

  • Gene Info — KRT13

    Entrez GeneID

    3860

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT13

    Gene Alias

    CK13, K13, MGC161462, MGC3781

    Gene Description

    keratin 13

    Omim ID

    148065 193900

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq

    Other Designations

    cytokeratin 13|keratin, type I cytoskeletal 13

  • Gene Info — KRT18

    Entrez GeneID

    3875

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT18

    Gene Alias

    CYK18, K18

    Gene Description

    keratin 18

    Omim ID

    148070 215600

    Gene Ontology

    Hyperlink

    Gene Summary

    KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

    Other Designations

    cell proliferation-inducing protein 46|cytokeratin 18

  • Gene Info — KRT6C

    Entrez GeneID

    286887

    Protein Accession#

    P02538 ; P04259 ; P13647 ; P19013 ; P48668

    Gene Name

    KRT6C

    Gene Alias

    K6E, KRT6E, MGC102925, MGC163455, MGC163457

    Gene Description

    keratin 6C

    Gene Ontology

    Hyperlink

    Gene Summary

    Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq

    Other Designations

    keratin 6E

  • Interactomes
  • Pathways
  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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