HEYL monoclonal antibody (M03), clone 2G1
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More Files
- More Functions
Immunofluorescence
Immunofluorescence of monoclonal antibody to HEYL on HeLa cell . [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (37.51 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant HEYL.
Immunogen
HEYL (NP_055386, 221 a.a. ~ 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (78); Rat (79)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.51 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to HEYL on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — HEYL
Entrez GeneID
26508GeneBank Accession#
NM_014571Protein Accession#
NP_055386Gene Name
HEYL
Gene Alias
HRT3, MGC12623, bHLHb33
Gene Description
hairy/enhancer-of-split related with YRPW motif-like
Omim ID
609034Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq
Other Designations
HEY-like protein|OTTHUMP00000000536|hairy-related transcription factor 3
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Interactome
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Publication Reference
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The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.
Manish Bodas, Bharathiraja Subramaniyan, Andrew R. Moore, Jordan P. Metcalf, Sarah R. Ocañas, Willard M. Freeman, Constantin Georgescu, Jonathan D. Wren, Matthew S. Walters.
Cells 2021 Nov; 10(11):3215.
Application：IF, Human, Mouse, Human bronchus, Mouse trachea.
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Activation of NOTCH1 or NOTCH3 Signaling Skews Human Airway Basal Cell Differentiation toward a Secretory Pathway.
Gomi K, Arbelaez V, Crystal RG, Walters MS.
PLoS One 2015 Feb; 10(2):e0116507.
Application：IF, IHC-P, Human, Airway basal cells.
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The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.
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