Products

Western Blot (Cell lysate)

PRKAB1 monoclonal antibody (M02), clone 2C3 Western Blot analysis of PRKAB1 expression in HeLa ( Cat # L013V1 ).

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged PRKAB1 is approximately 0.1ng/ml as a capture antibody.

ELISA

Immunofluorescence

Immunofluorescence of monoclonal antibody to PRKAB1 on HeLa cell. [antibody concentration 10 ug/ml]

Entrez GeneID

5564

GeneBank Accession#

BC001007

Protein Accession#

AAH01007

Gene Name

PRKAB1

Gene Alias

AMPK, HAMPKb, MGC17785

Gene Description

protein kinase, AMP-activated, beta 1 non-catalytic subunit

Omim ID

602740

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq

Other Designations

5'-AMP-activated protein kinase beta-1 subunit|AMP-activated protein kinase beta 1 non-catalytic subunit|AMP-activated protein kinase beta subunit|AMPK beta -1 chain|AMPK beta 1|protein kinase, AMP-activated, noncatalytic, beta-1