Products

Western Blot (Transfected lysate)

Western Blot analysis of NPPB expression in transfected 293T cell line by NPPB monoclonal antibody (M01), clone 2D11.

Lane 1: NPPB transfected lysate(14.726 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Immunoprecipitation

Immunoprecipitation of NPPB transfected lysate using anti-NPPB monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with NPPB MaxPab rabbit polyclonal antibody.

ELISA

Entrez GeneID

4879

GeneBank Accession#

BC025785

Protein Accession#

AAH25785

Gene Name

NPPB

Gene Alias

BNP

Gene Description

natriuretic peptide precursor B

Omim ID

600295

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq

Other Designations

OTTHUMP00000002506|OTTHUMP00000044486|brain type natriuretic peptide|natriuretic protein