COMT (Human) IP-WB Antibody Pair
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of COMT transfected lysate using rabbit polyclonal anti-COMT and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-COMT.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-COMT (300 ul)
2. Antibody pair for WB: mouse purified polyclonal anti-COMT (50 ug)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — COMT
Entrez GeneID
1312Gene Name
COMT
Gene Alias
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Gene Description
catechol-O-methyltransferase
Gene Ontology
HyperlinkGene Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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