CCND1 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CCND1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 147-175 of human CCND1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CCND1 polyclonal antibody (Cat # PAB2538) in mouse lung tissue lysates (35 ug/lane). CCND1 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — CCND1
Entrez GeneID
595Protein Accession#
NP_444284;Q6FI00Gene Name
CCND1
Gene Alias
BCL1, D11S287E, PRAD1, U21B31
Gene Description
cyclin D1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Other Designations
B-cell CLL/lymphoma 1|G1/S-specific cyclin D1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes.
He YY, Council SE, Feng L, Chignell CF.
Cancer Research 2008 May; 68(10):3752.
Application:WB-Tr, Human, HaCaT cells.
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A genotype-phenotype examination of cyclin D1 on risk and outcome of squamous cell carcinoma of the head and neck.
Marsit CJ, Black CC, Posner MR, Kelsey KT.
Clinical Cancer Research 2008 Apr; 14(8):2371.
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The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini.
Caldon CE, Swarbrick A, Lee CS, Sutherland RL, Musgrove EA.
Cancer Research 2008 Apr; 68(8):3026.
Application:WB, Human, MCF-10A cells.
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UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes.
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