SNAI2 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SNAI2.
Immunogen
A synthetic peptide corresponding to internal region 13 amino acids of human SNAI2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SNAI2 in 293 cell lysate with SNAI2 polyclonal antibody (Cat # PAB13228) at in (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunofluorescence
Immunofluorescence of SNAI2 in human kidney tissue with SNAI2 polyclonal antibody (Cat # PAB13228) at 20 ug/mL . -
Gene Info — SNAI2
Entrez GeneID
6591Protein Accession#
O43623Gene Name
SNAI2
Gene Alias
MGC10182, SLUG, SLUGH1, WS2D
Gene Description
snail homolog 2 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq
Other Designations
OTTHUMP00000195093|neural crest transcription factor SLUG|slug (chicken homolog), zinc finger protein|slug homolog, zinc finger protein|snail 2
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients.
Shioiri M, Shida T, Koda K, Oda K, Seike K, Nishimura M, Takano S, Miyazaki M.
British Journal of Cancer 2006 Jun; 94(12):1816.
Application:IHC-P, Human, Colorectal carcinoma.
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The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells.
Martínez-Estrada OM, Cullerés A, Soriano FX, Peinado H, Bolós V, Martínez FO, Reina M, Cano A, Fabre M, Vilaró S.
The Biochemical Journal 2006 Mar; 394(Pt 2):449.
Application:Func, Dog, MDCK (NBL-2).
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Control of cell behavior during vertebrate development by Slug, a zinc finger gene.
Nieto MA, Sargent MG, Wilkinson DG, Cooke J.
Science 1994 May; 264(5160):835.
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Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients.
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