CCND1 monoclonal antibody, clone SPM587
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CCND1 in cell lysates
Lane 1: C2C12 cell lysate
Lane 2: HepG2 cell lysate
Lane 3: NIH3T3 cell lysate
with CCND1 monoclonal antibody, clone SPM587 (Cat # MAB12020).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of Hodgkin's lymphoma with CCND1 monoclonal antibody, clone SPM587 (Cat # MAB12020).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CCND1.
Immunogen
Recombinant protein corresponding to full length human CCND1.
Host
Mouse
Theoretical MW (kDa)
36
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Immunohistochemistry (0.5-1 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CCND1 in cell lysates
Lane 1: C2C12 cell lysate
Lane 2: HepG2 cell lysate
Lane 3: NIH3T3 cell lysate
with CCND1 monoclonal antibody, clone SPM587 (Cat # MAB12020).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of Hodgkin's lymphoma with CCND1 monoclonal antibody, clone SPM587 (Cat # MAB12020). -
Gene Info — CCND1
Entrez GeneID
595Gene Name
CCND1
Gene Alias
BCL1, D11S287E, PRAD1, U21B31
Gene Description
cyclin D1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Other Designations
B-cell CLL/lymphoma 1|G1/S-specific cyclin D1
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Interactome
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Pathway
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Disease
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