APOA1 monoclonal antibody, clone 1405
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Specifications
Product Description
Mouse monoclonal antibody raised against native APOA1.
Immunogen
Native purified APOA1 from human plasma.
Host
Mouse
Reactivity
Human
Specificity
Recognizes human apolipoprotein AI. No cross reactivity with Apo A-II or Apo B.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.0 (0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Radioimmunoassay
Enzyme Immunoassay
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Gene Info — APOA1
Entrez GeneID
335Gene Name
APOA1
Gene Alias
MGC117399
Gene Description
apolipoprotein A-I
Gene Ontology
HyperlinkGene Summary
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq
Other Designations
OTTHUMP00000069346|OTTHUMP00000069347|OTTHUMP00000069348|apolipoprotein A1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Retrovirus-mediated expression of apolipoprotein A-I in the macrophage protects against atherosclerosis in vivo.
Ishiguro H, Yoshida H, Major AS, Zhu T, Babaev VR, Linton MF, Fazio S.
The Journal of Biological Chemistry 2001 Jul; 276(39):36742.
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An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells.
Jamil H, Gordon DA, Eustice DC, Brooks CM, Dickson JK Jr, Chen Y, Ricci B, Chu CH, Harrity TW, Ciosek CP Jr, Biller SA, Gregg RE, Wetterau JR.
PNAS 1996 Oct; 93(21):11991.
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Retrovirus-mediated expression of apolipoprotein A-I in the macrophage protects against atherosclerosis in vivo.
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