HTRA2 monoclonal antibody, clone 196C429
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot detection of HTRA2 in HL-60 cell lysate. Two protein bands of approximate molecular weight of 50 and 38 KDa were detected using HTRA2 monoclonal antibody, clone 196C429 (Cat # MAB0099) at 3 ug/mL dilution. The 50 KDa and 38 KDa bands may represent precursor and mature form of Omi.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
IHC testing using HTRA2 monoclonal antibody, clone 196C429 (Cat # MAB0099) shows cytoplasmic staining in stomach tumor tissue (A) and very weak staining in normal stomach tissue (B) .
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of HTRA2.
Immunogen
A synthetic peptide corresponding to amino acids 335-350 of human HTRA2.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot detection of HTRA2 in HL-60 cell lysate. Two protein bands of approximate molecular weight of 50 and 38 KDa were detected using HTRA2 monoclonal antibody, clone 196C429 (Cat # MAB0099) at 3 ug/mL dilution. The 50 KDa and 38 KDa bands may represent precursor and mature form of Omi.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
IHC testing using HTRA2 monoclonal antibody, clone 196C429 (Cat # MAB0099) shows cytoplasmic staining in stomach tumor tissue (A) and very weak staining in normal stomach tissue (B) . -
Gene Info — HTRA2
Entrez GeneID
27429Gene Name
HTRA2
Gene Alias
OMI, PARK13, PRSS25
Gene Description
HtrA serine peptidase 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq
Other Designations
HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25
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Interactome
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Disease
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Publication Reference
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X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia.
Wang X, Zhu C, Wang X, Hagberg H, Korhonen L, Sandberg M, Lindholm D, Blomgren K.
Neurobiology of Disease 2004 Jun; 16(1):179.
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Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
Lee SH, Lee JW, Kim HS, Kim SY, Park WS, Kim SH, Lee JY, Yoo NJ.
APMIS 2003 May; 111(5):586.
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X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia.
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