HTRA2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of HTRA2 in human colon cell lysates with HTRA2 polyclonal antibody (Cat # PAB13117) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of HTRA2 in human colon tissue with HTRA2 polyclonal antibody (Cat # PAB13117) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HTRA2.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human HTRA2.
Host
Rabbit
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of HTRA2 in human colon cell lysates with HTRA2 polyclonal antibody (Cat # PAB13117) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of HTRA2 in human colon tissue with HTRA2 polyclonal antibody (Cat # PAB13117) at 10 ug/mL . -
Gene Info — HTRA2
Entrez GeneID
27429Protein Accession#
AAB94569Gene Name
HTRA2
Gene Alias
OMI, PARK13, PRSS25
Gene Description
HtrA serine peptidase 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq
Other Designations
HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25
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Interactome
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Disease
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Publication Reference
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The inhibitors of apoptosis: there is more to life than Bcl2.
Liston P, Fong WG, Korneluk RG.
Oncogene 2003 Nov; 22(53):8568.
Application：WB-Tr, Human, Mammalian cells.
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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R.
Molecular Cell 2001 Sep; 8(3):613.
Application：IF, WB, Human, HeLa cells.
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An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif.
Crook NE, Clem RJ, Miller LK.
Journal of Virology 1993 Apr; 67(4):2168.
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The inhibitors of apoptosis: there is more to life than Bcl2.
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