CAMK2A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CAMK2A.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CAMK2A.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CAMK2A polyclonal antibody (Cat # PAB2770) in HL-60 cell lysate. CAMK2A (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with CAMK2A polyclonal antibody (Cat # PAB2770) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — CAMK2A
Entrez GeneID
815Protein Accession#
Q9UQM7Gene Name
CAMK2A
Gene Alias
CAMKA, KIAA0968
Gene Description
calcium/calmodulin-dependent protein kinase II alpha
Omim ID
114078Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
CaM kinase II alpha subunit|CaM-kinase II alpha chain|CaMK-II alpha subunit|CaMKIINalpha|OTTHUMP00000165787|OTTHUMP00000165788|calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha|calcium/calmodulin-dependent protein kinase II alpha-B subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Oncogenic kinase signalling.
Blume-Jensen P, Hunter T.
Nature 2001 May; 411(6835):355.
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Phosphoinositide 3-kinase signalling pathways.
Cantrell DA.
Journal of Cell Science 2001 Apr; 114(Pt 8):1439.
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The RET proto-oncogene in human cancers.
Jhiang SM.
Oncogene 2000 Nov; 19(49):5590.
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Oncogenic kinase signalling.
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