CDKN1C polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CDKN1C in 293 cell lysate with CDKN1C polyclonal antibody (Cat # PAB25634) at (1) 1 and (2) 2 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDKN1C.
Immunogen
A synthetic peptide corresponding to 17 amino acids at N-terminus of human CDKN1C.
Host
Rabbit
Theoretical MW (kDa)
35
Reactivity
Human
Specificity
At least three isoforms of CDKN1C are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, CDKN1C often migrates at 57kDa in SDS-PAGE. CDKN1C antibody is predicted to not cross react with other CIP/KIP proteins.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CDKN1C in 293 cell lysate with CDKN1C polyclonal antibody (Cat # PAB25634) at (1) 1 and (2) 2 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDKN1C
Entrez GeneID
1028Protein Accession#
NP_000067Gene Name
CDKN1C
Gene Alias
BWCR, BWS, KIP2, WBS, p57
Gene Description
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000011736|cyclin-dependent kinase inhibitor 1C
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Interactome
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Pathway
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Disease
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