ABCA1 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ABCA1.
Immunogen
A synthetic peptide corresponding to amino acids 1100-1300 of human ABCA1.
Host
Rabbit
Theoretical MW (kDa)
220
Reactivity
Hamster, Human, Mouse, Rat
Specificity
This antibody is specific to ABCA1.
Form
Liquid
Purification
Immunogen affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Flow Cytometry (1:400)
Immunocytochemistry (1:100)
Immunofluorescence (1:100)
Immunohistochemistry (1:200)
Immunoprecipitation (1:10-1:500)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Detection of ABCA1 in mouse peritoneal macrophages using ABCA1 polyclonal antibody (Cat # PAB12504). Lane 1 : T09 uninduced lysate, Lane 2 : T09 induced lysate.Flow Cytometry
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Gene Info — ABCA1
Entrez GeneID
19Protein Accession#
O95477Gene Name
ABCA1
Gene Alias
ABC-1, ABC1, CERP, FLJ14958, HDLDT1, MGC164864, MGC165011, TGD
Gene Description
ATP-binding cassette, sub-family A (ABC1), member 1
Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq
Other Designations
ATP binding cassette transporter 1|ATP-binding cassette 1|ATP-binding cassette, sub-family A member 1|OTTHUMP00000021833|cholesterol efflux regulatory protein|membrane-bound
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells.
Stokes E, Shuang T, Zhang Y, Pei Y, Fu M, Guo B, Parissenti A, Wu L, Wang R, Yang G.
Life Sciences 2018 Nov; 213:116.
Application:WB-Ce, Human, HepG2 cell lysates.
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Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis.
Bhatnagar S, Damron HA, Hillgartner FB.
The Journal of Biological Chemistry 2009 Feb; 284(15):10023.
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Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y.
The Journal of Biological Chemistry 2009 Jan; 284(10):6218.
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ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity.
Nandi S, Ma L, Denis M, Karwatsky J, Li Z, Jiang XC, Zha X.
Journal of Lipid Research 2009 Mar; 50(3):456.
Application:IF, Mouse, BHK cells.
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Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.
Nakanishi S, Vikstedt R, Soderlund S, Lee-Rueckert M, Hiukka A, Ehnholm C, Muilu M, Metso J, Naukkarinen J, Palotie L, Kovanen PT, Jauhiainen M, Taskinen MR.
Journal of Lipid Research 2009 Feb; 50(2):183.
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Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.
Henry-Berger J, Mouzat K, Baron S, Bernabeu C, Marceau G, Saru JP, Sapin V, Lobaccaro JM, Caira F.
Biology of Reproduction 2008 Jun; 78(6):968.
Application:WB-Ce, Human, JAR cells.
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Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells.
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