ATR polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ATR.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S428 of human ATR.
Sequence
GISPK
Host
Rabbit
Theoretical MW (kDa)
250
Reactivity
Human
Specificity
ATR (Ab-428) Antiobdy detects endogenous levels of total ATR protein.
Form
Liquid
Purification
Immunoaffinity purification
Concentration
1 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATR polyclonal antibody (Cat # PAB12228). -
Gene Info — ATR
Entrez GeneID
545Protein Accession#
Q13535Gene Name
ATR
Gene Alias
FRP1, MEC1, SCKL, SCKL1
Gene Description
ataxia telangiectasia and Rad3 related
Gene Ontology
HyperlinkOther Designations
FRAP-related protein-1|MEC1, mitosis entry checkpoint 1, homolog|Rad3 related protein|ataxia telangiectasia and Rad3 related protein|protein kinase ATR
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of DNA replication by ATR: signaling in response to DNA intermediates.
Shechter D, Costanzo V, Gautier J.
DNA Repair 2004 Aug; 3(8-9):901.
Application:IHC, WB, Human, Cancers, Mammalian cells.
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The many substrates and functions of ATM.
Kastan MB, Lim DS.
Molecular and Cellular Biology 2000 Dec; 1(3):179.
Application:IHC, IP, WB-Ce, WB-Tr, Human, Cancers, Mammalian cells.
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Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism.
Zhou XZ, Lu PJ, Wulf G, Lu KP.
Cellular and Molecular Life Sciences 1999 Nov; 56(9-10):788.
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Regulation of DNA replication by ATR: signaling in response to DNA intermediates.
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