CDKN2A polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of CDKN2A.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDKN2A.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase staining of formalin-fixed paraffin-embedded human tonsil. Expression is seen in the mantle zone aand the majority of cells in the germinal center are negative. -
Gene Info — CDKN2A
Entrez GeneID
1029Gene Name
CDKN2A
Gene Alias
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19
Gene Description
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Gene Ontology
HyperlinkGene Summary
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq
Other Designations
CDK4 inhibitor p16-INK4|OTTHUMP00000021147|OTTHUMP00000021148|cell cycle negative regulator beta|cyclin-dependent kinase inhibitor 2A|cyclin-dependent kinase inhibitor p16|multiple tumor suppressor 1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Dissecting the senescence-like program in tumor cells activated by Ras signaling.
Bihani T, Chicas A, Lo CP, Lin AW.
The Journal of Biological Chemistry 2006 Nov; 282(4):2666.
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Expression of p16INK4A variants in senescent human fibroblasts independent of protein phosphorylation.
Weebadda WK, Jackson TJ, Lin AW.
Journal of Cellular Biochemistry 2005 Jan; 94(6):1135.
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Differential oncogenic Ras signaling and senescence in tumor cells.
Bihani T, Mason DX, Jackson TJ, Chen SC, Boettner B, Lin AW.
Cell Cycle 2004 Sep; 3(9):1201.
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Dissecting the senescence-like program in tumor cells activated by Ras signaling.
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