ITGAX monoclonal antibody, clone 3.9 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGAX.
Immunogen
Native purified from human rheumatoid synovial fluid cells and fibronectin purified human monocytes.
Host
Mouse
Reactivity
Human
Specificity
Specificity human CD11c
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
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Gene Info — ITGAX
Entrez GeneID
3687Gene Name
ITGAX
Gene Alias
CD11C, SLEB6
Gene Description
integrin, alpha X (complement component 3 receptor 4 subunit)
Omim ID
151510Gene Ontology
HyperlinkGene Summary
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq
Other Designations
OTTHUMP00000163299|integrin alpha X|integrin, alpha X (antigen CD11C (p150), alpha polypeptide)|leu M5, alpha subunit|leukocyte surface antigen p150,95, alpha subunit|myeloid membrane antigen, alpha subunit|p150 95 integrin alpha chain
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Interactome
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Pathway
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Disease
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Publication Reference
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The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion.
G E Davis.
Experimental Cell Research 1992 Jun; 200(2):242.
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Structure and function of leukocyte integrins.
Larson RS, Springer TA.
Immunological Reviews 1990 Apr; 114:181.
Application：Flow Cyt, Human, Leukocytes, Mammalian cells.
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The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.
Hogg N, Takacs L, Palmer DG, Selvendran Y, Allen C.
European Journal of Immunology 1986 Mar; 16(3):240.
Application：IHC, IP, Human, Brains, Dermatopathic lymphadenopathy sample, Gut, Hair-cell leukemia, Lung, Monocytes, Neutrophils, Skin, Spleen, Tonsil, U937 cells.
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The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion.
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