TNFRSF10A monoclonal antibody, clone DR-4-02 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant TNFRSF10A.
Immunogen
Recombinant Fc fusion protein corresponding to extracellular region of TNFRSF10A.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived.
Form
Liquid
Conjugation
FITC
Concentration
0.1 mg/mL
Isotype
IgG1
Recommend Usage
Flow Cytometry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — TNFRSF10A
Entrez GeneID
8797Gene Name
TNFRSF10A
Gene Alias
APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1
Gene Description
tumor necrosis factor receptor superfamily, member 10a
Omim ID
603611Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq
Other Designations
TNF-related apoptosis inducing ligand receptor 1|cytotoxic TRAIL receptor|death receptor 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
Simova S, Klima M, Cermak L, Sourkova V, Andera L.
Apoptosis 2008 Mar; 13(3):423.
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TRAIL, caspases and maturation of normal and leukemic myeloid precursors.
Corallini F, Milani D, Nicolin V, Secchiero P.
Leukemia & Lymphoma 2006 Aug; 47(8):1459.
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Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
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