Flow cytometric analysis of K562 cells with CRKL (phospho Tyr207) monoclonal antibody, clone G4 (APC)(Cat # MAB23353). Unstained (blue) as negative control or treated with imatinib (red) or treated with pervanadate (green)
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic