HLA-DRB5 MaxPab mouse polyclonal antibody (B02)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human HLA-DRB5 protein.
Immunogen
HLA-DRB5 (NP_002116, 1 a.a. ~ 266 a.a) full-length human protein.
Sequence
MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLLFLGAGLFIYFKNQKGHSGLHPTGLVS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (74); Rat (70)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of HLA-DRB5 expression in transfected 293T cell line (H00003127-T02) by HLA-DRB5 MaxPab polyclonal antibody.
Lane 1: HLA-DRB5 transfected lysate(29.26 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — HLA-DRB5
Entrez GeneID
3127GeneBank Accession#
NM_002125Protein Accession#
NP_002116Gene Name
HLA-DRB5
Gene Alias
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Gene Description
major histocompatibility complex, class II, DR beta 5
Omim ID
604776Gene Ontology
HyperlinkGene Summary
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
Other Designations
HLA class II histocompatibility antigen, DR-5 beta chain|MHC HLA-DR-beta cell surface glycoprotein|MHC HLA-DR-beta chain|MHC class II HLA beta chain|MHC class II antigen|OTTHUMP00000029035|human leucocyte antigen DRB5|leukocyte antigen class II
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Interactome
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Pathway
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Disease
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